Mild Forms of Alport Syndrome: Hereditary Nephropathy in the Absence of Extra-Renal Features
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منابع مشابه
Clinical data and hearing of individuals with Alport syndrome.
UNLABELLED Alport Syndrome (AS) is a hereditary disease, characterized by nephropathy, often times with sensorineural hearing loss and ocular defects. AIM to analyze the clinical and hearing information from individuals with AS, more specifically the correlation between renal disorder and hearing loss (HL). STUDY DESIGN clinical prospective with cross-sectional cohort. MATERIALS AND METHO...
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25 The renal biopsy tissue from a 9-month-old, male Pyrenean Mountain dog with 26 renal disorder and severe proteinuria was examined. Ultrastructural examination 27 revealed multilaminar splitting and fragmentation of the glomerular basement 28 membrane (GBM) and diffuse podocyte foot process effacement. 29 Immunofluorescent staining for α(IV) chains revealed presence of α5(IV) and 30 complete ...
متن کاملPathological features of proteinuric nephropathy resembling Alport syndrome in a young Pyrenean Mountain dog
The renal biopsy tissue from a 9-month-old, male Pyrenean Mountain dog with renal disorder and severe proteinuria was examined. Ultrastructural examination revealed multilaminar splitting and fragmentation of the glomerular basement membrane (GBM) and diffuse podocyte foot process effacement. Immunofluorescent staining for α(IV) chains revealed presence of α5(IV) and complete absence of α3(IV) ...
متن کاملThe renal lesions of Alport syndrome.
Alport syndrome is a hereditary, progressive, hematuric nephropathy characterized by glomerular basement membrane abnormalities with frequent hearing defects and ocular anomalies. The disease is associated with mutations in genes encoding the alpha3, alpha4, or alpha5 chains of type IV collagen, COL4A3, or COL4A4 in the autosomal forms of the disease, COL4A5 in the more frequent X-linked variet...
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The effect and outcome of pregnancy in patients with chronic idiopathic glomerulonephritis was studied. The study population consisted of 98 patients. All patients were divided into 8 groups according to presence, absence or coexistence of 3 general risk factors such as hypertension, renal failure and nephrotic syndrome. The adverse effect of renal disease and risk factors on the outcome of pre...
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